Mechanisms underlying FeCl3-induced arterial thrombosis.

  title={Mechanisms underlying FeCl3-induced arterial thrombosis.},
  author={Anita Eckly and B{\'e}atrice Hechler and Monique Freund and Murielle Zerr and J. P. Cazenave and François Lanza and Pierre Henri Mangin and Christian Gachet},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={9 4},
BACKGROUND The FeCl(3)-induced vascular injury model is widely used to study thrombogenesis in vivo, but the processes leading to vascular injury and thrombosis are poorly defined. OBJECTIVES The aim of our study was to better characterize the mechanisms of FeCl(3)-induced vascular injury and thrombus formation, in order to evaluate the pathophysiological relevance of this model. METHODS FeCl(3) was applied at different concentrations (from 7.5% to 20%) and for different time periods (up to… CONTINUE READING
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