Mechanisms underlying "functional" progesterone withdrawal at parturition.

  title={Mechanisms underlying "functional" progesterone withdrawal at parturition.},
  author={Amy G Brown and Rita S Leite and Jerome F Strauss},
  journal={Annals of the New York Academy of Sciences},
Progesterone is a major factor maintaining uterine quiescence throughout pregnancy. In most species, peripheral progesterone levels decline before initiation of labor, and treatments that inhibit progesterone synthesis or action cause termination of pregnancy and/or premature deliveries. These findings suggest that progesterone withdrawal is required for activation of myometrial contractions. However, in humans, circulating progesterone levels remain elevated until birth, which leads to the… CONTINUE READING

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