Mechanisms through which Sos-1 coordinates the activation of Ras and Rac

  title={Mechanisms through which Sos-1 coordinates the activation of Ras and Rac},
  author={Metello Innocenti and Pierluigi Tenca and Emanuela Frittoli and Mario Faretta and Arianna Tocchetti and Pier Paolo Di Fiore and Giorgio Scita},
  journal={The Journal of Cell Biology},
  pages={125 - 136}
Signaling from receptor tyrosine kinases (RTKs)* requires the sequential activation of the small GTPases Ras and Rac. Son of sevenless (Sos-1), a bifunctional guanine nucleotide exchange factor (GEF), activates Ras in vivo and displays Rac-GEF activity in vitro, when engaged in a tricomplex with Eps8 and E3b1-Abi-1, a RTK substrate and an adaptor protein, respectively. A mechanistic understanding of how Sos-1 coordinates Ras and Rac activity is, however, still missing. Here, we demonstrate that… CONTINUE READING
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