Mechanisms that regulate stem cell aging and life span.

@article{Signer2013MechanismsTR,
  title={Mechanisms that regulate stem cell aging and life span.},
  author={Robert A J Signer and Sean J Morrison},
  journal={Cell stem cell},
  year={2013},
  volume={12 2},
  pages={
          152-65
        }
}
Mammalian aging is associated with reduced tissue regeneration, increased degenerative disease, and cancer. Because stem cells regenerate many adult tissues and contribute to the development of cancer by accumulating mutations, age-related changes in stem cells likely contribute to age-related morbidity. Consistent with this, stem cell function declines with age in numerous tissues as a result of gate-keeping tumor suppressor expression, DNA damage, changes in cellular physiology, and… CONTINUE READING
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