Mechanisms responsible for beneficial and adverse effects of rosiglitazone in a rat model of acute cardiac ischaemia-reperfusion.

@article{Palee2013MechanismsRF,
  title={Mechanisms responsible for beneficial and adverse effects of rosiglitazone in a rat model of acute cardiac ischaemia-reperfusion.},
  author={Siripong Palee and Punate Weerateerangkul and Kroekkiat Chinda and Siriporn C Chattipakorn and Nipon Chattipakorn},
  journal={Experimental physiology},
  year={2013},
  volume={98 5},
  pages={1028-37}
}
Despite debate regarding its cardioprotective and pro-arrhythmic effects, the precise mechanisms of action of rosiglitazone on the heart are still unclear. We determined the mechanistic effects of rosiglitazone on cardiac function, arrhythmias and infarct size during cardiac ischaemia-reperfusion. Twenty-six rats were used. In each rat, either rosiglitazone or saline solution was administered intravenously prior to a 30 min left anterior descending coronary artery ligation and a 120 min… CONTINUE READING
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