Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.

  title={Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.},
  author={Daotai Nie and Sriram Krishnamoorthy and Rongxian Jin and Keqin Tang and YuChyu Chen and Yan Qiao and Alex Zacharek and Yande Guo and Julie Milanini and Gilles Pag{\'e}s and Kenneth V. Honn},
  journal={The Journal of biological chemistry},
  volume={281 27},
12-Lipoxygenase utilizes arachidonic acid to synthesize 12(S)-hydroperoxyeicosatetraenoic acid, which is converted to the end product 12(S)-hydroxyeicosatetraenoic acid, an eicosanoid that promotes tumorigenesis and metastasis. Increased expression of 12-lipoxygenase has been documented in a number of carcinomas. When overexpressed in human prostate or breast cancer, 12-lipoxygenase promotes tumor angiogenesis and growth in vivo. The present study was undertaken to delineate the mechanisms by… CONTINUE READING


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