Mechanisms regulating the constitutive activation of the extracellular signal-regulated kinase (ERK) signaling pathway in ovarian cancer and the effect of ribonucleic acid interference for ERK1/2 on cancer cell proliferation.

@article{Steinmetz2004MechanismsRT,
  title={Mechanisms regulating the constitutive activation of the extracellular signal-regulated kinase (ERK) signaling pathway in ovarian cancer and the effect of ribonucleic acid interference for ERK1/2 on cancer cell proliferation.},
  author={Rosemary Steinmetz and Heather A. Wagoner and Pingyu Zeng and Jessica R Hammond and Tamara S. Hannon and Justin L Meyers and Ora Hirsch Pescovitz},
  journal={Molecular endocrinology},
  year={2004},
  volume={18 10},
  pages={2570-82}
}
The ERK1/2 MAPK pathway is a critical signaling system that mediates ligand-stimulated signals for the induction of cell proliferation, differentiation, and cell survival. Studies have shown that this pathway is constitutively active in several human malignancies and may be involved in the pathogenesis of these tumors. In the present study we examined the ERK1/2 pathway in cell lines derived from epithelial and granulosa cell tumors, two distinct forms of ovarian cancer. We show that ERK1 and… CONTINUE READING
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