Mechanisms regulating macrophage-induced nitric oxide production by spontaneously transformed hamster fibroblasts.

@article{Lavnikova1996MechanismsRM,
  title={Mechanisms regulating macrophage-induced nitric oxide production by spontaneously transformed hamster fibroblasts.},
  author={Natasha Lavnikova and Svetlana Prokhorova and L G Burdelia and A V Lakhotia and Debra L. Laskin},
  journal={Journal of leukocyte biology},
  year={1996},
  volume={60 4},
  pages={473-9}
}
Nitric oxide has been implicated as an important effector molecule involved in tumor cell growth and cytotoxicity. In these studies we examined mechanisms regulating nitric oxide production by hamster tumor cells. Cocultures of hamster alveolar macrophages (HAM) and spontaneously transformed hamster embryonic fibroblasts (STHE cells) produced significant quantities of nitric oxide in response to lipopolysaccharide (LPS). Culture supernatants from HAM treated with LPS also stimulated nitric… CONTINUE READING
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