Mechanisms regulating increased production of osteoprotegerin by osteoblasts cultured on microstructured titanium surfaces.

@article{Schwartz2009MechanismsRI,
  title={Mechanisms regulating increased production of osteoprotegerin by osteoblasts cultured on microstructured titanium surfaces.},
  author={Zvi Schwartz and Ren{\'e} Olivares-Navarrete and Marco Wieland and David Lee Cochran and Barbara D Boyan},
  journal={Biomaterials},
  year={2009},
  volume={30 20},
  pages={3390-6}
}
Osteoblasts grown on microstructured Ti surfaces enhance osteointegration by producing local factors that regulate bone formation as well as bone remodeling, including the RANK ligand decoy receptor osteoprotegerin (OPG). The objective of this study was to explore the mechanism by which surface microstructure and surface energy mediate their stimulatory effects on OPG expression. Titanium disks were manufactured to present different surface morphologies: a smooth pretreatment surface (PT, Ra<0… CONTINUE READING
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Integrin a2b1 plays a critical role in the response of osteoblasts to micron scale surface structure and surface energy of titanium substrates

  • R Olivares-Navarrete, P Raz, G Zhao, M Wieland, DL Cochran, RA Chaudhri
  • Proc Natl Acad Sci U S A 2008;105:15767–72
  • 2008
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