Mechanisms regulating angiotensin II responsiveness by the uteroplacental circulation.

  title={Mechanisms regulating angiotensin II responsiveness by the uteroplacental circulation.},
  author={Charles R Rosenfeld},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={281 4},
Pregnancy is associated with increases in cardiac output and uterine blood flow (UBF) and a fall in systemic vascular resistance. In ovine pregnancy, UBF rises from approximately 3% of cardiac output to approximately 25% at term gestation, reflecting a >30-fold rise in UBF by term. This increase in UBF supports exponential fetal growth during the last trimester and maintains fetal well-being by providing excess oxygen and nutrient delivery. These hemodynamic changes are associated with numerous… CONTINUE READING
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