Mechanisms of viral membrane fusion and its inhibition.

@article{Eckert2001MechanismsOV,
  title={Mechanisms of viral membrane fusion and its inhibition.},
  author={Debra M. Eckert and Peter S. Kim},
  journal={Annual review of biochemistry},
  year={2001},
  volume={70},
  pages={
          777-810
        }
}
Viral envelope glycoproteins promote viral infection by mediating the fusion of the viral membrane with the host-cell membrane. Structural and biochemical studies of two viral glycoproteins, influenza hemagglutinin and HIV-1 envelope protein, have led to a common model for viral entry. The fusion mechanism involves a transient conformational species that can be targeted by therapeutic strategies. This mechanism of infectivity is likely utilized by a wide variety of enveloped viruses for which… 

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