Mechanisms of vasorelaxation induced by the cannabidiol analogue compound O-1602 in the rat small mesenteric artery.

@article{Suleimani2015MechanismsOV,
  title={Mechanisms of vasorelaxation induced by the cannabidiol analogue compound O-1602 in the rat small mesenteric artery.},
  author={Yousuf M Al Suleimani and Ahmed S Al Mahruqi and C. Robin Hiley},
  journal={European journal of pharmacology},
  year={2015},
  volume={765},
  pages={107-14}
}
Atypical cannabinoid O-1602 (5-Methyl-4-[(1R,6R)-3-methyl-6-(1-cyclohexen-1-yl]-1,3-benzenediol) induces vasorelaxation and activates the orphan G protein-coupled receptor GPR55 in human endothelial cells. This study investigates the underlying mechanisms of vasorelaxation induced by this compound. The vasodilator activity was assessed in the rat third… CONTINUE READING