Mechanisms of vasculitis: how pauci-immune is ANCA-associated renal vasculitis?

  title={Mechanisms of vasculitis: how pauci-immune is ANCA-associated renal vasculitis?},
  author={Pieter van Paassen and Jan Willem Cohen Tervaert and Peter Heeringa},
  journal={Nephron. Experimental nephrology},
  volume={105 1},
Both the innate and the acquired immune system are involved in the pathophysiology of renal vasculitis. However, anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis is characterized by a 'pauci-immune' pattern of immunofluorescence during kidney biopsy, indicating the relative lack of immunoglobulin and complement deposition within the kidney. On the other hand, evidence is accumulating that ANCA, autoantibodies against constituents of primary granules of neutrophils and the… CONTINUE READING
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