Mechanisms of varicose vein formation: valve dysfunction and wall dilation

  title={Mechanisms of varicose vein formation: valve dysfunction and wall dilation},
  author={Joseph D. Raffetto and Raouf A. Khalil},
  pages={85 - 98}
Abstract Varicose veins are a common venous disease of the lower extremity. Although the mechanisms and determinants in the development of varicosities are not clearly defined, recent clinical studies and basic science research have cast some light on possible mechanisms of the disease. In varicose veins, there are reflux and incompetent valves as well as vein wall dilation. Primary structural changes in the valves may make them ‘leaky’, with progressive reflux causing secondary changes in the… 

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