Mechanisms of use-dependent plasticity in the human motor cortex.

  title={Mechanisms of use-dependent plasticity in the human motor cortex.},
  author={Cathrin M. Buetefisch and Brian C Davis and Steven P. Wise and Lumy Sawaki and Leonid Y Kopylev and Joseph Classen and Leonardo G. Cohen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 7},
Practicing movements results in improvement in performance and in plasticity of the motor cortex. To identify the underlying mechanisms, we studied use-dependent plasticity in human subjects premedicated with drugs that influence synaptic plasticity. Use-dependent plasticity was reduced substantially by dextromethorphan (an N-methyl-d-aspartate receptor blocker) and by lorazepam [a gamma-aminobutyric acid (GABA) type A receptor-positive allosteric modulator]. These results identify N-methyl-d… CONTINUE READING
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