Mechanisms of type-I- and type-II-interferon-mediated signalling

@article{Platanias2005MechanismsOT,
  title={Mechanisms of type-I- and type-II-interferon-mediated signalling},
  author={Leonidas C. Platanias},
  journal={Nature Reviews Immunology},
  year={2005},
  volume={5},
  pages={375-386}
}
  • L. Platanias
  • Published 1 May 2005
  • Biology, Medicine
  • Nature Reviews Immunology
Interferons are cytokines that have antiviral, antiproliferative and immunomodulatory effects. Because of these important properties, in the past two decades, major research efforts have been undertaken to understand the signalling mechanisms through which these cytokines induce their effects. Since the original discovery of the classical JAK (Janus activated kinase)–STAT (signal transducer and activator of transcription) pathway of signalling, it has become clear that the coordination and… Expand
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The role of signal transducer and activator of transcription-2 in the interferon response.
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