Mechanisms of tumor invasion: evidence from in vivo observations

  title={Mechanisms of tumor invasion: evidence from in vivo observations},
  author={Helmut Erich Gabbert},
  journal={Cancer and Metastasis Reviews},
The major mechanisms of tumor invasion in vivo are discussed in the present review. A special emphasis is placed on tumor dedifferentiation which has proved to be of paramount importance for the invasion process. Based on in vivo observations obtained from various human and animal tumors a concept for the mechanism of tumor invasion is proposed which mainly comprises the following basic events: the first and essential step in tumor invasion is the tumor dedifferentiation and dissociation at the… CONTINUE READING