Mechanisms of tubulointerstitial injury in IgA nephropathy.

@article{Lai2005MechanismsOT,
  title={Mechanisms of tubulointerstitial injury in IgA nephropathy.},
  author={Kar Neng Lai and Loretta Y. Y. Chan and Joseph C K Leung},
  journal={Kidney international. Supplement},
  year={2005},
  volume={94},
  pages={
          S110-5
        }
}
BACKGROUND IgA nephropathy (IgAN) runs a highly variable clinical course, with frequent involvement of tubulointerstitial damage. A subgroup of IgAN with severe tubulointerstitial damage is often associated with the most rapid progression to end-stage renal failure. In IgAN, mesangial sclerosis and tubulointerstitial damage were found to be correlated with the increase in pore size of the glomerular barrier. METHODS The direct toxicity of proximal tubular epithelial cells (PTEC) by IgA in… CONTINUE READING

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PATHOLOGY OF IgA NEPHROPATHY

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