Mechanisms of tubulo-interstitial injury in progressive renal diseases.

@article{Fine1993MechanismsOT,
  title={Mechanisms of tubulo-interstitial injury in progressive renal diseases.},
  author={Leon G. Fine and Albert C. M. Ong and Jill T. Norman},
  journal={European journal of clinical investigation},
  year={1993},
  volume={23 5},
  pages={259-65}
}
A vast amount of evidence, based upon human renal biopsy material, indicates that the presence of tubular atrophy and interstitial fibrosis is a better indicator of outcome of renal function than is the extent of glomerular sclerosis. The pathophysiological basis for this surprising fact has not been adequately addressed. In this review we point out that the systemic hypertension which accompanies most forms of chronic renal disease could impact adversely upon the vasodilated interstitial… CONTINUE READING

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