Mechanisms of trimethoprim resistance in enterobacteria isolated in Finland.

@article{Then1981MechanismsOT,
  title={Mechanisms of trimethoprim resistance in enterobacteria isolated in Finland.},
  author={Rudolf L Then and Feodora Hermann},
  journal={Chemotherapy},
  year={1981},
  volume={27 3},
  pages={192-9}
}
Dihydrofolate reductases (DHFR) were studied in two groups of trimethoprim (TMP)-resistant Enterobacteria, isolated in Turku, Finland. The first group consisted of six strains with a high level of TMP resistance (MIC greater than 1,000 mg/l) and all of them were found to harbour an additional TMP-insensitive DHFR thought to be responsible for the high degree of resistance. Three Proteus mirabilis strains in this group synthesized chromosomal reductases with reduced TMP sensitivity as well. A… CONTINUE READING

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