Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs.

  title={Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs.},
  author={Steve Bourgault and Sungwook Choi and Joel N Buxbaum and Jeffery W Kelly and Joshua L Price and Nat{\`a}lia Reixach},
  journal={Biochemical and biophysical research communications},
  volume={410 4},
The transthyretin amyloidoses are a subset of protein misfolding diseases characterized by the extracellular deposition of aggregates derived from the plasma homotetrameric protein transthyretin (TTR) in peripheral nerves and the heart. We have established a robust disease-relevant human cardiac tissue culture system to explore the cytotoxic effects of amyloidogenic TTR variants. We have employed this cardiac amyloidosis tissue culture model to screen 23 resveratrol analogs as inhibitors of… CONTINUE READING
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