Mechanisms of transformation by the BCR/ABL oncogene.

  title={Mechanisms of transformation by the BCR/ABL oncogene.},
  author={Martin Sattler and James D Griffin},
  journal={International journal of hematology},
  volume={73 3},
The Philadelphia chromosome generates a chimeric oncogene in which the BCR and c-ABL genes are fused. The product of this oncogene, BCR/ABL, has elevated ABL tyrosine kinase activity, relocates to the cytoskeleton, and phosphorylates multiple cellular substrates. BCR/ABL transforms hematopoietic cells and exerts a wide variety of biological effects, including reduction in growth factor dependence, enhanced viability, and altered adhesion of chronic myelocytic leukemia (CML) cells. Elevated… CONTINUE READING