Mechanisms of transcriptional synergism of eukaryotic genes. The interferon-beta paradigm.

@article{Thanos1996MechanismsOT,
  title={Mechanisms of transcriptional synergism of eukaryotic genes. The interferon-beta paradigm.},
  author={Dimitris Thanos},
  journal={Hypertension},
  year={1996},
  volume={27 4},
  pages={1025-9}
}
The virus-inducible enhancer of the human interferon-beta gene has served as an excellent example for the mechanisms controlling the activation and repression of transcription. This enhancer is activated by three different transcription factors that, with the help of the high mobility group protein HMG I(Y), assemble in a unique nucleoprotein complex that interacts as a unit with the basal transcriptional machinery. The assembly of unique enhancer complexes from similar sets of transcription… CONTINUE READING