Mechanisms of tolerance to self.

  title={Mechanisms of tolerance to self.},
  author={Jacques F. A. P. Miller and Antony Basten},
  journal={Current opinion in immunology},
  volume={8 6},
Several mechanisms exist to prevent lymphocytes from reacting against self-antigens. As T cells develop in the thymus and express antigen-specific receptors, those with high-affinity to self-antigens existing within the thymus are deleted. Low-affinity self-reactive T cells and T cells with receptors against antigens not represented intrathymically will mature and join the peripheral T cell pool. They may either ignore self-antigens expressed by tissues unable to activate T cells through a lack… CONTINUE READING

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