Mechanisms of thyroid hormone receptor action during development: lessons from amphibian studies.

@article{Grimaldi2013MechanismsOT,
  title={Mechanisms of thyroid hormone receptor action during development: lessons from amphibian studies.},
  author={Alexis G. Grimaldi and Nicolas Buisine and Thomas Miller and Yunbo Shi and Laurent M. Sachs},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1830 7},
  pages={3882-92}
}
BACKGROUND Thyroid hormone (TH) receptor (TR) plays critical roles in vertebrate development. However, the in vivo mechanism of TR action remains poorly explored. SCOPE OF REVIEW Frog metamorphosis is controlled by TH and mimics the postembryonic period in mammals when high levels of TH are also required. We review here some of the findings on the developmental functions of TH and TR and the associated mechanisms obtained from this model system. MAJOR CONCLUSION A dual function model for TR… CONTINUE READING
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