Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies.

@article{Ribeiro1998MechanismsOT,
  title={Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies.},
  author={Ralff C. J. Ribeiro and James W. Apriletti and Richard L. Wagner and Brian L West and Weijun Feng and Robert Huber and Peter J. Kushner and Stefan Nilsson and Thomas S. Scanlan and Robert Fletterick and Fred Schaufele and J. D. Baxter},
  journal={Recent progress in hormone research},
  year={1998},
  volume={53},
  pages={351-92; discussion 392-4}
}
This review summarizes the studies conducted in our laboratory on the mechanisms of thyroid hormone action over the past two decades. We have attempted to place our studies on thyroid hormone receptors (TRs) in perspective with the work conducted by other investigators that established their nuclear localization, DNA-binding properties, DNA response elements, and the role of other proteins involved in TR-mediated regulation of gene transcription. Recently, our crystallographic studies of the TR… CONTINUE READING