Mechanisms of the stereoselective interaction between miconazole and racemic warfarin in human subjects.

@article{Oreilly1992MechanismsOT,
  title={Mechanisms of the stereoselective interaction between miconazole and racemic warfarin in human subjects.},
  author={Robert A. O'reilly and D A Goulart and Kent L. Kunze and Jessie Neal and Milo Gibaldi and Andrew C. Eddy and William F. Trager},
  journal={Clinical pharmacology and therapeutics},
  year={1992},
  volume={51 6},
  pages={
          656-67
        }
}
Miconazole decreased the total body clearance of both (R)- and (S)-warfarin in normal subjects but did not change volumes of distribution. Miconazole inhibited the oxidation of both (R)- and (S)-warfarin to phenolic metabolites, although (S)-warfarin was inhibited to the greater extent. In particular, (S)-7-hydroxylation, the pathway primarily responsible for termination of the anticoagulant effect, was most strongly inhibited. Inhibition of warfarin hydroxylation by miconazole in human liver… CONTINUE READING
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