Mechanisms of the initiation of protein synthesis: in reading frame binding of ribosomes to mRNA

@article{Nakamoto2010MechanismsOT,
  title={Mechanisms of the initiation of protein synthesis: in reading frame binding of ribosomes to mRNA},
  author={T. Nakamoto},
  journal={Molecular Biology Reports},
  year={2010},
  volume={38},
  pages={847-855}
}
  • T. Nakamoto
  • Published 2010
  • Biology, Medicine
  • Molecular Biology Reports
The various mechanisms proposed to describe the initiation of protein synthesis are reviewed with a focus on their initiation signals. A characteristic feature of the various mechanisms is that each one of them postulates a distinct initiation signal. The signals of the Shine–Dalgarno (SD), the scanning and the internal ribosome entry site (IRES) mechanisms are all located exclusively in the 5′ leader sequence, whereas, the signal of the cumulative specificity (CS) mechanism includes the entire… Expand
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