Mechanisms of the genotoxic effects associated with 5-formyluracil: effect of exogenous 5'-formyl-2'-deoxyuridine.

@article{Ide1997MechanismsOT,
  title={Mechanisms of the genotoxic effects associated with 5-formyluracil: effect of exogenous 5'-formyl-2'-deoxyuridine.},
  author={Hiroshi Ide and Hiroaki Terato and Aya Masaoka and Nobuyuki Nagasawa and Yoshihiko Ohyama},
  journal={Nucleic acids symposium series},
  year={1997},
  volume={37},
  pages={
          165-6
        }
}
E. coli HB101 harboring plasmid pUC19 was grown in the presence of 5-formyl-2'-deoxyuridine (fdU) to evaluate the genotoxic and cytotoxic potentials associated with this DNA lesion. Cell growth was inhibited by fdU in a concentration-dependent manner, but increased mutation was not observed in the lacZ(alpha) gene of pUC19. The lack of the mutagenic effect was attributed to poor utilization of fdU as a substrate by thymidine kinase, which converts exogenous thymidine analogs to the… CONTINUE READING

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