Mechanisms of the biphasic effects of peroxides on the retinal vasculature of newborn and adult pigs.

@article{Abran1995MechanismsOT,
  title={Mechanisms of the biphasic effects of peroxides on the retinal vasculature of newborn and adult pigs.},
  author={Daniel Abran and Pierre Hardy and D. Ramesh Varma and Sylvain Chemtob},
  journal={Experimental eye research},
  year={1995},
  volume={61 3},
  pages={285-92}
}
We tested whether the ontogenic differences in the constrictor effects of peroxides on the retinal vasculature were modulated by dilator cyclo-oxygenase products. Retinal arteriole (100-200 microns) vasomotor response to H2O2, t-butyl hydroperoxide, and cumene hydroperoxide were studied in isolated eyecup preparations using video camera monitoring of vessel diameter. A time- and dose-dependent biphasic retinal vasomotor response to all peroxides was observed on tissues of newborn and adult pigs… CONTINUE READING