Mechanisms of the antinociceptive action of gabapentin.

@article{Cheng2006MechanismsOT,
  title={Mechanisms of the antinociceptive action of gabapentin.},
  author={Jen-Kun Cheng and Lih-Chu Chiou},
  journal={Journal of pharmacological sciences},
  year={2006},
  volume={100 5},
  pages={471-86}
}
Gabapentin, a gamma-aminobutyric acid (GABA) analogue anticonvulsant, is also an effective analgesic agent in neuropathic and inflammatory, but not acute, pain systemically and intrathecally. Other clinical indications such as anxiety, bipolar disorder, and hot flashes have also been proposed. Since gabapentin was developed, several hypotheses had been proposed for its action mechanisms. They include selectively activating the heterodimeric GABA(B) receptors consisting of GABA(B1a) and GABA(B2… CONTINUE READING

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