Mechanisms of the antinociceptive action of (−) Epicatechin obtained from the hydroalcoholic fraction of Combretum leprosum Mart & Eic in rodents

@inproceedings{Lopes2011MechanismsOT,
  title={Mechanisms of the antinociceptive action of (−) Epicatechin obtained from the hydroalcoholic fraction of Combretum leprosum Mart & Eic in rodents},
  author={Luciano da Silva Lopes and Rosemarie Brandin Marques and Heliana de Barros Fernandes and Sergio da Silva Pereira and Mariane CC Ayres and Mariana Helena Chaves and Fernanda R C Almeida},
  booktitle={Journal of Biomedical Science},
  year={2011}
}
The mechanisms of the antinociceptive activity of (−) epicatechin (EPI), a compound isolated from the hydroalcoholic fraction of Combreum leprosum Mart & Eicher. were assessed in the model of chemical nociception induced by glutamate (20 μmol/paw). To evaluate the mechanisms involved, the animals , male Swiss mice (25-30 g), received EPI (50 mg/kg p.o.) after pretreatment with naloxone (2 mg/kg s.c. opioid antagonist), glibenclamide (2 mg/kg s.c. antagonist K + channels sensitive to ATP… CONTINUE READING
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