Mechanisms of the antidiabetic effects of the β3-adrenergic agonist CL-316243 in obese Zucker-ZDF rats.

@article{Liu1998MechanismsOT,
  title={Mechanisms of the antidiabetic effects of the β3-adrenergic agonist CL-316243 in obese Zucker-ZDF rats.},
  author={Xilin Liu and Fleurette P{\'e}russe and Ludwik J Bukowiecki},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={1998},
  volume={274 5},
  pages={R1212-R1219}
}
Previous studies have demonstrated that chronic cold exposure activates the sympathetic nervous system, increases energy expenditure, improves glucose tolerance, enhances insulin sensitivity, and stimulates glucose uptake in peripheral tissues [brown and white adipose tissues (BAT and WAT) and muscles] of normal rats. The goal of the present studies was to test whether the selective β3-adrenergic agonist CL-316243 (CL) would mimic the beneficial effects of cold exposure in lean and obese ZDF… CONTINUE READING
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