Mechanisms of the anti-ischemic effect of vagus nerve stimulation in the gerbil hippocampus.

@article{Miyamoto2003MechanismsOT,
  title={Mechanisms of the anti-ischemic effect of vagus nerve stimulation in the gerbil hippocampus.},
  author={O. Miyamoto and Jinming Pang and Kazunori Sumitani and Tetsuro Negi and Yoshiaki Hayashida and Toshifumi Itano},
  journal={Neuroreport},
  year={2003},
  volume={14 15},
  pages={1971-4}
}
The neuroprotective mechanisms of cervical vagus nerve stimulation (VNS) in transient ischemia were investigated. Left VNS (0.4 mA, 40 Hz) was performed during 5 min ischemia in gerbils. About 50% of the hippocampal neurons were rescued from ischemic insult by VNS, and this effect was prevented by transection of the vagus nerve centrally to the site of cervical stimulation. VNS significantly attenuated both ischemia-induced glutamate release and transient increase of hippocampal blood flow… CONTINUE READING
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