Mechanisms of the anti‐inflammatory effects of glucocorticoids: genomic and nongenomic interference with MAPK signaling pathways

@article{Ayroldi2012MechanismsOT,
  title={Mechanisms of the anti‐inflammatory effects of glucocorticoids: genomic and nongenomic interference with MAPK signaling pathways},
  author={Emira Ayroldi and Lorenza Cannarile and Graziella Migliorati and Giuseppe Nocentini and Domenico Vittorio Delfino and Carlo Riccardi},
  journal={The FASEB Journal},
  year={2012},
  volume={26},
  pages={4805 - 4820}
}
Glucocorticoids (GCs) are steroid hormones produced by the adrenal gland and regulated by the hypothalamus‐pituitary‐adrenal axis. GCs mediate effects that mostly result in transcriptional regulation of glucocorticoid receptor target genes. Mitogen‐activated protein kinases (MAPKs) comprise a family of signaling proteins that convert extracellular stimuli into the activation of intracellular transduction pathways via phosphorylation of a cascade of substrates. They modulate a variety of… Expand
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