Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance.

@article{Basu2003MechanismsOT,
  title={Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance.},
  author={R. Basu and E. Breda and A. Oberg and C. Powell and C. Dalla Man and A. Basu and J. Vittone and G. Klee and P. Arora and M. Jensen and G. Toffolo and C. Cobelli and R. Rizza},
  journal={Diabetes},
  year={2003},
  volume={52 7},
  pages={
          1738-48
        }
}
Glucose tolerance decreases with age. For determining the cause of this decrease, 67 elderly and 21 young (70.1 +/- 0.7 vs. 23.7 +/- 0.8 years) participants ingested a mixed meal and received an intravenous injection of glucose. Fasting glucose and the glycemic response above basal were higher in the elderly than in the young participants after either meal ingestion (P < 0.001) or glucose injection (P < 0.01). Insulin action (Si), measured with the meal and intravenous glucose tolerance test… Expand
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