Mechanisms of the acute effects of inhaled ozone in humans.

  title={Mechanisms of the acute effects of inhaled ozone in humans.},
  author={Philip A. Bromberg},
  journal={Biochimica et biophysica acta},
  volume={1860 12},
Ambient air ozone (O3) is generated photochemically from oxides of nitrogen and volatile hydrocarbons. Inhaled O3 causes remarkably reversible acute lung function changes and inflammation. Approximately 80% of inhaled O3 is deposited on the airways. O3 reacts rapidly with CC double bonds in hydrophobic airway and alveolar surfactant-associated phospholipids and cholesterol. Resultant primary ozonides further react to generate bioactive hydrophilic products that also initiate lipid peroxidation… CONTINUE READING