Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.

@article{Han2004MechanismsOT,
  title={Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.},
  author={Ke-jun Han and Xiaoqin Su and Liang-Guo Xu and Liang-Hua Bin and Jun Zhang and Hong-Bing Shu},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 15},
  pages={15652-61}
}
Toll-like receptor-3 is critically involved in host defense against viruses through induction of type I interferons (IFNs). Recent studies suggest that a Toll/interleukin-1 receptor domain-containing adapter protein (TRIF) and two protein kinases (TANK-binding kinase-1 (TBK1) and IkappaB kinase (IKK)-epsilon) are critically involved in Toll-like receptor-3-mediated IFN-beta production through activation of IFN regulatory factor (IRF)-3 and IRF-7. In this study, we demonstrate that TRIF… CONTINUE READING