Mechanisms of synergism in the mutagenicity of cadmium and N-methyl-N-nitrosourea in Salmonella typhimurium: the effect of pH.

@article{Mandel1987MechanismsOS,
  title={Mechanisms of synergism in the mutagenicity of cadmium and N-methyl-N-nitrosourea in Salmonella typhimurium: the effect of pH.},
  author={Richard J Mandel and H. J. Ryser},
  journal={Mutation research},
  year={1987},
  volume={176 1},
  pages={1-10}
}
Cadmium enhances the mutagenic effect of N-methyl-N-nitrosourea (MNU) in a synergistic manner in Salmonella typhimurium. In the range of doses that yield synergistic effects, it is by itself highly cytotoxic and only weakly mutagenic. A decrease in pH from 7 to 6 markedly decreases cadmium toxicity, causing a 4-fold increase in the surviving fraction. The… CONTINUE READING