Mechanisms of surface-tension-induced epithelial cell damage in a model of pulmonary airway reopening.


Airway collapse and reopening due to mechanical ventilation exerts mechanical stress on airway walls and injures surfactant-compromised lungs. The reopening of a collapsed airway was modeled experimentally and computationally by the progression of a semi-infinite bubble in a narrow fluid-occluded channel. The extent of injury caused by bubble progression to… (More)


10 Figures and Tables