Mechanisms of surface antigenic variation in the 2 human pathogenic fungus Pneumocystis jirovecii

@inproceedings{SchmidSiegert2017MechanismsOS,
  title={Mechanisms of surface antigenic variation in the 2 human pathogenic fungus Pneumocystis jirovecii},
  author={Emanuel Schmid-Siegert and Sophie Richard and Amanda Luraschi and Konrad Muehlethaler and Marco Pagni and Philippe M Hauser},
  year={2017}
}
36 Microbial pathogens commonly escape the human immune system by varying surface proteins. 37 We investigated the mechanisms used for that purpose by Pneumocystis jirovecii. This 38 uncultivable fungus is an obligate pulmonary pathogen which causes pneumonia in immuno39 compromised individuals, a major life-threatening infection. Long-read PacBio sequencing was 40 used to assemble a core of subtelomeres of a single P. jirovecii strain from a bronchoalveolar 41 lavage fluid specimen of a single… CONTINUE READING