Mechanisms of successful amoxicillin prophylaxis of experimental endocarditis due to Streptococcus intermedius.

@article{Moreillon1986MechanismsOS,
  title={Mechanisms of successful amoxicillin prophylaxis of experimental endocarditis due to Streptococcus intermedius.},
  author={Philippe Moreillon and Patrick B. Francioli and D Overholser and Pascal R. A. Meylan and Michel Pierre Glauser},
  journal={The Journal of infectious diseases},
  year={1986},
  volume={154 5},
  pages={801-7}
}
Prophylaxis with amoxicillin (40 mg/kg) was studied in rats with aortic valve vegetations. Bacteria on the valves were quantitated early (10 min to 6 hr) and late (three days) after intravenous challenge with tolerant Streptococcus intermedius. Amoxicillin reduced by 40% the number of bacteria per valve 10 min after intravenous challenge with 10(5) S. intermedius (P less than .05) and by 74% the incidence of endocarditis three days thereafter (P less than .0001). Bacterial multiplication… CONTINUE READING

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