Mechanisms of substrate transport-induced clustering of a glial glutamate transporter GLT-1 in astroglial-neuronal cultures.

@article{Nakagawa2008MechanismsOS,
  title={Mechanisms of substrate transport-induced clustering of a glial glutamate transporter GLT-1 in astroglial-neuronal cultures.},
  author={Takayuki Nakagawa and Yasuto Otsubo and Yumi Yatani and Hisashi Shirakawa and Shuji Kaneko},
  journal={The European journal of neuroscience},
  year={2008},
  volume={28 9},
  pages={1719-30}
}
Glutamate uptake by the Na(+)-dependent glutamate transporter GLT-1, which is predominantly expressed in astrocytes, is crucial for regulating glutamate concentration at the synaptic cleft and achieving proper excitatory neurotransmission. A body of evidence suggests that GLT-1 constitutively traffics between the plasma membrane and endosomes via an endocytosis/recycling pathway, and forms a cluster. Here, we report substrate transport via GLT-1-induced formation of GLT-1 cluster accompanied by… CONTINUE READING

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