Mechanisms of subcutaneous absorption of rituximab in rats.

  title={Mechanisms of subcutaneous absorption of rituximab in rats.},
  author={Leonid Kagan and Donald E Mager},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={41 1},
Absorption of monoclonal antibodies (mAbs) after s.c. injection results from the interplay among several kinetic processes. The aims of this study were to investigate the absorption mechanisms of rituximab in rats by using slow s.c. infusion and coadministration with nonspecific IgG or hyaluronidase, and to evaluate the predictive performance of the pharmacokinetic model previously developed to describe the nonlinear absorption behavior of mAbs. Rituximab serum concentrations were measured… CONTINUE READING