Mechanisms of spreading depression and hypoxic spreading depression-like depolarization.

  title={Mechanisms of spreading depression and hypoxic spreading depression-like depolarization.},
  author={G. G. Somjen},
  journal={Physiological reviews},
  volume={81 3},
  • G. Somjen
  • Published 1 July 2001
  • Biology
  • Physiological reviews
Spreading depression (SD) and the related hypoxic SD-like depolarization (HSD) are characterized by rapid and nearly complete depolarization of a sizable population of brain cells with massive redistribution of ions between intracellular and extracellular compartments, that evolves as a regenerative, "all-or-none" type process, and propagates slowly as a wave in brain tissue. This article reviews the characteristics of SD and HSD and the main hypotheses that have been proposed to explain them… 

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