Mechanisms of spontaneous and chemically-induced aneuploidy in mammalian oogenesis: basis of sex-specific differences in response to aneugens and the necessity for further tests.


The basis for sex-specific differences in chemically-induced and age-related aneuploidy of mammalian germ cells is still unknown. We have analysed the maturation of isolated mouse oocytes to characterize the mechanisms underlying drug-induced aneuploidy produced by two compounds, chloral hydrate (CH) and diazepam (DZ). When administered in vivo both drugs… (More)