Mechanisms of spontaneous activity in developing spinal networks.

  title={Mechanisms of spontaneous activity in developing spinal networks.},
  author={Michael J. O'Donovan and Nikolai Chub and Peter Wenner},
  journal={Journal of neurobiology},
  volume={37 1},
Developing networks of the chick spinal cord become spontaneously active early in development and remain so until hatching. Experiments using an isolated preparation of the spinal cord have begun to reveal the mechanisms responsible for this activity. Whole-cell and optical recordings have shown that spinal neurons receive a rhythmic, depolarizing synaptic drive and experience rhythmic elevations of intracellular calcium during spontaneous episodes. Activity is expressed throughout the neuraxis… CONTINUE READING
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