Mechanisms of specificity in protein phosphorylation

  title={Mechanisms of specificity in protein phosphorylation},
  author={Jeffrey A. Ubersax and James E Ferrell},
  journal={Nature Reviews Molecular Cell Biology},
A typical protein kinase must recognize between one and a few hundred bona fide phosphorylation sites in a background of ∼700,000 potentially phosphorylatable residues. Multiple mechanisms have evolved that contribute to this exquisite specificity, including the structure of the catalytic site, local and distal interactions between the kinase and substrate, the formation of complexes with scaffolding and adaptor proteins that spatially regulate the kinase, systems-level competition between… CONTINUE READING
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