Mechanisms of sodium pump regulation.


The Na(+)-K(+)-ATPase, or sodium pump, is the membrane-bound enzyme that maintains the Na(+) and K(+) gradients across the plasma membrane of animal cells. Because of its importance in many basic and specialized cellular functions, this enzyme must be able to adapt to changing cellular and physiological stimuli. This review presents an overview of the many mechanisms in place to regulate sodium pump activity in a tissue-specific manner. These mechanisms include regulation by substrates, membrane-associated components such as cytoskeletal elements and the gamma-subunit, and circulating endogenous inhibitors as well as a variety of hormones, including corticosteroids, peptide hormones, and catecholamines. In addition, the review considers the effects of a range of specific intracellular signaling pathways involved in the regulation of pump activity and subcellular distribution, with particular consideration given to the effects of protein kinases and phosphatases.

4 Figures and Tables

Citations per Year

3,772 Citations

Semantic Scholar estimates that this publication has 3,772 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Therien2000MechanismsOS, title={Mechanisms of sodium pump regulation.}, author={Alex G. Therien and Rhoda Blostein}, journal={American journal of physiology. Cell physiology}, year={2000}, volume={279 3}, pages={C541-66} }