Mechanisms of sodium azide-induced changes in intracellular calcium concentration in rat primary cortical neurons.

@article{Marino2007MechanismsOS,
  title={Mechanisms of sodium azide-induced changes in intracellular calcium concentration in rat primary cortical neurons.},
  author={Silvia Marino and Luca Marani and Cristiano Nazzaro and Lorenzo Beani and Anna Maria Siniscalchi},
  journal={Neurotoxicology},
  year={2007},
  volume={28 3},
  pages={
          622-9
        }
}
An intracellular calcium ([Ca(2+)](i)) increase is involved in sodium azide (NaN(3))-induced neurotoxicity, an in vitro model of brain ischemia. In this study the questions of possible additional sources of calcium influx, besides glutamate receptor activation, and of the time-course of NaN(3) effects have been addressed by measuring [Ca(2+)](i) in rat primary cortical cultures with the FURA-2 method. Basal [Ca(2+)](i) of neuronal populations was concentration-dependently increased 30 min, but… CONTINUE READING

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